Lung scRNA-seq Data from Mice with Osteogenesis Imperfecta, Revealing Chronic Inflammation

Single-cell RNA sequencing data from the lungs of Col1a1^Aga2/+ mice, a model for osteogenesis imperfecta. The dataset, 6.8 MB in size and last updated in March 2026, was created by Jennifer Zieba to investigate pulmonary complications. Analysis reveals increased AT2 to AT1 cell transition in young mice, fibroblast activation in adults, and a chronic inflammation phenotype.

Use Cases

• Identify cell-type-specific gene expression changes based on the described chronic inflammation phenotype.
• Analyze pathways related to IL1B, TNF, and NOD-like receptor signaling activation mentioned in the description.
• Investigate alveolar cell development and dysfunction based on the reported AT2 to AT1 transition and decreased Scgb1a1 expression.
• Study fibroblast activation and differentiation in a genetic disease context as described for adult mice.

Strengths

• Data is derived from a specific and well-characterized mouse model (Col1a1^Aga2/+) for a rare disease.
• Includes samples from both young and adult mice, allowing for developmental stage comparisons.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• Data is from a controlled mouse model; direct applicability to human OI patients may be limited.

Provenance

Source

Jennifer Zieba via figshare.

Collection Method

Single-cell RNA sequencing (scRNAseq) of lung tissue from a genetically modified mouse model.

Time Range

The data collection timeframe is not specified.

Freshness

Last updated 2026-03-17 13:07:57; freshness should be verified.

Geography

Not applicable; data is from a laboratory mouse model.