Mouse Lung Proteomics and Cytokine Data for Millettia Speciosa Asthma Study

179 differentially expressed proteins were identified in a mouse model of allergic asthma treated with the herb Millettia speciosa. The dataset includes proteomic and cytokine profiling results showing suppression of CCL24 and Th2 inflammation. Author Hangrui Yang published the data on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Identify potential drug targets based on the 179 differentially expressed proteins.
• Study the role of the CCL24-eosinophil axis in allergic inflammation.
• Analyze immunometabolic pathway modulation, such as PPAR signaling and lipid transport.
• Investigate correlations between proteomic changes and cytokine levels like IL-4, IL-5, and IL-6.

Strengths

• Includes proteomic analysis revealing 179 differentially expressed proteins.
• Integrates cytokine profiling data showing reductions in IgE, IL-4, IL-5, and IL-6.
• Data is published under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 5.2 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• The link to the gut-lung axis is noted as hypothetical and not directly investigated in the study.

Provenance

Source

figshare

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics integrated with cytokine profiling from an ovalbumin-induced mouse model.

Freshness

Last updated 2026-06-03 07:42:21; freshness should be verified.