N-acyl-homoserine Lactone Quorum Sensing Data in Underexplored Bacterial Lineages

A 1.1 MB PDF research article by Christy R. Handel, last updated in April 2026, investigates AHL-based quorum sensing beyond canonical bacterial lineages. The study uses custom hidden Markov models and LC-MRM-MS to analyze putative luxI/R homologs and AHL production in bacteria from environments like a Hawaiian taro lo‘i and a Bahamian hypersaline mat. Findings suggest AHL signaling in Actinomycetota may operate through regulatory frameworks distinct from classical systems.

Use Cases

• Training models to identify novel quorum sensing gene homologs based on the described custom HMM methodology.
• Analyzing the genomic context and phylogeny of luxI/R-family proteins in non-model bacteria.
• Studying the diversity of AHL signaling architectures across different bacterial phyla.
• Investigating the link between AHL production and genes linked to metabolism and redox processes in Actinomycetota.

Strengths

• Data is associated with a peer-reviewed research article describing novel findings.
• The dataset is openly available under a CC-BY-4.0 license.
• Analysis includes targeted gene disruption experiments confirming gene function.

Limitations

• The primary data file is a 1.1 MB PDF; underlying raw data (e.g., sequences, spectra) may not be directly accessible.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset's scale is small, which may restrict direct machine learning applications.

Provenance

Source

figshare

Collection Method

Research involving genomic analysis, custom HMMs, and liquid chromatography-mass spectrometry (LC-MRM-MS).

Time Range

Publication date suggests research was conducted prior to 2026.

Freshness

Last updated 2026-04-20 05:20:45

Geography

Includes samples from Hawai‘i (USA) and San Salvador Island (Bahamas).