Mouse Brain Transcriptomic Profiles for High-Altitude Injury and Oxygen Therapy

A 54.2 KB PDF data sheet from a study analyzing the effects of normobaric and hyperbaric oxygen therapy on high-altitude cerebral injury in mice. The dataset, authored by Xiaojie Hu and last updated in April 2026, includes results from RNA sequencing, histopathology, and biochemical assays. It likely contains gene expression data and pathway analysis results from four experimental groups.

Use Cases

• Identify differentially expressed genes based on RNA-seq data from brain tissue under hypoxic conditions.
• Validate molecular pathway enrichment based on KEGG analysis results for NF-κB, PI3K-AKT, and IL-17 signaling.
• Correlate therapeutic outcomes based on oxidative stress markers (SOD, MDA, GSH, NO) and cytokine levels (IL-1β, IL-6, TNF-α).
• Compare treatment efficacy based on transcriptomic restoration patterns between normobaric and hyperbaric oxygen therapy.

Strengths

• Data is derived from a controlled animal model with four distinct treatment groups (Control, HH, NBO, HBO).
• Analysis integrates multiple validation methods: RNA-seq, Western blot, immunofluorescence, and ELISA.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 54.2 KB file size suggests the dataset is a summary or data sheet, not the raw sequencing data.

Provenance

Source

figshare, author Xiaojie Hu

Collection Method

Generated from a mouse model exposed to simulated high-altitude (7,000 m) hypoxia, followed by oxygen therapy and multi-omics analysis.

Time Range

Experimental timeframe not specified in metadata.

Freshness

Last updated 2026-04-13 05:49:14; freshness should be verified.

Geography

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