Data Sheet 7_ALDH1A1-dopaminergic gene co-expression in human substantia nigra: meta-analy

A meta-analysis of gene expression correlations across seven independent human substantia nigra microarray datasets, comprising 156 samples (70 controls, 86 Parkinson's disease). The dataset was created by Drake H. Harbert and last updated in May 2026. It examines the relationship between ALDH1A1 expression and dopaminergic pathway genes in Parkinson's disease.

Use Cases

• Validate gene co-expression changes in Parkinson's disease based on the meta-analysis of seven datasets.
• Study the selectivity of ALDH1A1 correlation attenuation relative to other dopaminergic genes.
• Perform secondary analyses on pooled correlation estimates and heterogeneity statistics provided by the meta-analysis.
• Investigate the relationship between cell type enrichment changes and gene co-expression patterns.

Strengths

• Analysis integrates seven independent datasets, providing a multi-study perspective.
• Includes results from permutation testing (n=5,000) and random-effects meta-analysis.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (923.0 B), indicating it contains summary statistics rather than raw expression data.

Provenance

Source

Gene Expression Omnibus (GEO) via figshare

Collection Method

Meta-analysis of seven independent human substantia nigra microarray datasets.

Freshness

Last updated 2026-05-19 05:30:34