CLL Cell-Derived Soluble Factors and Normal B Cell Functionality

A 173.0 KB PDF document published on figshare by Michelle Maria Elbert on May 15, 2026. It describes a study investigating whether soluble factors from chronic lymphocytic leukemia (CLL) cells impair the function of normal B cells from healthy donors. The research involved in vitro co-culture assays measuring plasma cell differentiation, proliferation, cell death, and activation markers.

Use Cases

• Analyzing B-cell activation based on CD80, CD86, and CD25 marker expression mentioned in the description
• Comparing plasma cell differentiation rates between CLL patient serum and healthy control serum
• Investigating B-cell proliferation and cell death levels in T-cell-dependent stimulation assays
• Testing hypotheses about humoral immunodeficiency in CLL patients based on in vitro co-culture results

Strengths

• Data is openly licensed under CC-BY-4.0 for reuse.
• The experimental methodology is described in detail, including controls and measured outcomes.

Limitations

• The dataset is small at 173.0 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

In vitro functional B-cell assays using serum from CLL patients and conditioned medium from CLL cells.

Freshness

Last updated 2026-05-15 05:52:10; freshness should be verified.