Mouse Model Data on PD-L1 Role in Shock/Sepsis-Induced Lung Injury

Elizabeth W. Tindal published this dataset on figshare in 2026. It contains experimental results from a study using Cre-lox mouse models to investigate the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The data likely includes mortality rates, lung permeability measurements, and cytokine/chemokine levels from bronchoalveolar lavage fluid, lung tissue, and blood samples.

Use Cases

• Analyze the differential impact of endothelial cell vs. neutrophil PD-L1 deficiency on mortality based on the 14-day survival study results.
• Investigate changes in lung vascular permeability based on Evan’s Blue dye exclusion assay results.
• Examine correlations between PD-L1 deficiency and cytokine/chemokine levels (e.g., MCP-1, MIP-2, IL-6, Angiopoietin 2) in lung tissue and BALF.
• Compare organ injury indices and blood urea nitrogen levels between genetically modified mouse strains and control groups.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific (endothelial vs. neutrophil) PD-L1 knockout.
• Includes multiple biological endpoints: survival, lung permeability, and cytokine/chemokine/angiopoietin levels from blood, BALF, and lung tissue.
• Published under a CC-BY-4.0 license, permitting open reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (44.2 KB), indicating a limited scope of experimental results.

Provenance

Source

figshare

Collection Method

Experimental data from a laboratory study using murine hemorrhagic shock and cecal ligation and puncture (CLP) models.

Freshness

Last updated 2026-06-02 04:31:29; freshness should be verified.