Laron Mouse Liver RNA-seq Data: Gene Therapy Response and Sex-Bias Analysis

RNA sequencing data from the livers of male and female mice, including wild-type, GH receptor knockout (Laron), and gene therapy treatment groups. The dataset was created by Joshua K. Tay and published on figshare under a CC-BY-4.0 license, with a last update recorded for May 2026. It contains expression data for thousands of genes, with specific counts provided for differentially expressed sets.

Use Cases

• Identify differentially expressed genes based on comparisons between wild-type, knockout, and treatment groups described in the study.
• Analyze the upregulation of GH-responsive IGF signaling genes (Igf1, Igfals) in response to gene therapy.
• Investigate the enrichment of sex-biased genes among those dysregulated by GHR loss and treatment.
• Examine the expression of specific proto-oncogenes (Ascl1, Tmprss4) reported to be upregulated beyond wild-type levels.

Strengths

• Explicit differential expression counts are provided: 448 genes changed with treatment versus 2781 with GHR knockout.
• Includes specific fold-change data for key genes like Igf1 and Igfals (~16-fold).
• Data is derived from a controlled experiment with multiple defined groups (wild-type, knockout, treatment, vector control).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 58.5 KB, indicating limited scope or a summary-level extract.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Joshua K. Tay.

Collection Method

RNA sequencing performed on mouse livers from a controlled laboratory experiment involving gene therapy with an AAV vector.

Freshness

Last updated 2026-05-28 04:56:29; freshness should be verified.