Integrated Stress Response Gene Biomarkers for Ankylosing Spondylitis

Transcriptomic and Mendelian randomization data identifies RORA, FBXO31, and MSRB3 as causal biomarkers for ankylosing spondylitis. The 35.8 KB Excel file contains results from differential gene expression analysis, causal inference, and drug prediction studies. Author Shuai Wang published the findings in 2026 under a CC BY 4.0 license.

Use Cases

• Validate the causal association of RORA, FBXO31, and MSRB3 expression with AS risk using Mendelian randomization results.
• Analyze correlations between identified biomarker genes and immune cell infiltration, particularly Th1 cells and keratinocytes.
• Investigate predicted therapeutic agents like indirubin and pentoxifylline based on the drug prediction analysis.
• Explore functional enrichment results linking the biomarkers to olfactory transduction pathways.

Strengths

• Includes results from multiple analytical methods: transcriptomics, Mendelian randomization, functional enrichment, and drug prediction.
• Findings are validated with RT–qPCR on clinically collected blood samples.
• Published under a permissive CC BY 4.0 license for reuse.

Limitations

• Dataset is very small at 35.8 KB, indicating limited raw data or a summary of results only.
• Unknown row and column structure; the XLSX file likely contains processed results, not primary sequencing data.
• Geographic origin and sample size for the clinical validation are not specified.

Provenance

Source

Shuai Wang via figshare.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, Mendelian randomization analysis, followed by RT–qPCR validation.

Time Range

null

Freshness

Last updated in March 2026.

Geography

null