Mouse Lung Proteomics and Cytokine Data for Millettia Speciosa Asthma Treatment Study

Proteomic and cytokine data from an ovalbumin-induced mouse model of allergic asthma, investigating the therapeutic effects of the herb Millettia speciosa (Niudali). The dataset, authored by Hangrui Yang and last updated in June 2026, includes results from high-resolution data-independent acquisition (DIA) lung proteomics and bronchoalveolar lavage fluid analyses, identifying 179 differentially expressed proteins.

Use Cases

• Identify key protein biomarkers for eosinophilic inflammation based on the 179 differentially expressed proteins.
• Study the mechanism of CCL24 suppression in asthma treatment based on proteomic findings.
• Analyze immunometabolic pathway modulation based on enriched pathways like complement cascades and PPAR signaling.
• Investigate the role of hub proteins like Alb, Apoe, and Apoa1 in immune regulation and lipid metabolism.

Strengths

• Includes results from high-resolution DIA proteomics, a detailed analytical method.
• Identifies 179 differentially expressed proteins with specific findings on CCL24 suppression.
• Integrates proteomic data with cytokine profiling (IgE, IL-4, IL-5, IL-6) for validation.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Dataset size is 5.1 KB, indicating a very limited scope, likely a summary of findings rather than raw data.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The described link to the gut-lung axis is noted as hypothetical and not directly investigated in the study.

Provenance

Source

figshare, author Hangrui Yang.

Collection Method

Generated from an ovalbumin-induced mouse model using DIA lung proteomics and cytokine profiling.

Freshness

Last updated 2026-06-03 07:42:21.