Data Sheet 7_Transcriptomic profiling and targeted validation reveal molecular mechanisms

A 2026 study by Xiaojie Hu investigates the molecular mechanisms of normobaric and hyperbaric oxygen therapy for high-altitude cerebral injury. The dataset likely contains RNA-seq results, pathway analyses, and validation data from a mouse model exposed to simulated 7,000 m altitude. It is shared as a 47.0 KB PDF on figshare under a CC-BY-4.0 license.

Use Cases

• Identify differentially expressed genes associated with high-altitude cerebral injury based on RNA-seq results.
• Analyze enrichment in signaling pathways like NF-κB, PI3K–AKT, and IL-17 based on KEGG pathway analysis.
• Validate therapeutic effects by correlating transcriptomic changes with oxidative stress markers (SOD, MDA, GSH, NO).
• Compare the molecular efficacy of normobaric versus hyperbaric oxygen therapy based on pathway modulation data.

Strengths

• Includes multi-modal validation data combining RNA-seq, Western blot, immunofluorescence, and ELISA.
• Study design compares four distinct treatment groups (Control, HH, NBO, HBO).
• Explicitly targets key molecular pathways (PI3K–AKT/Nrf2, TLR4–NF-κB) for mechanistic insight.

Limitations

• Dataset is a 47.0 KB PDF; the underlying raw sequencing or numerical data may not be directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the publication.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

Xiaojie Hu via figshare.

Collection Method

Data generated from a controlled laboratory study using a mouse model in a hypobaric hypoxia chamber.

Time Range

Study period not specified; dataset reflects a 2026 publication.

Freshness

Last updated 2026-04-13 05:49:13.

Geography

Laboratory study; geographic origin not specified.