Data Sheet 7: Multi-Omics Analysis of Xinnaoxin Tablets for High-Altitude Cardiac Injury

Zhihui Wang published a 63.9 KB PDF research data sheet on figshare in 2026. The document details a systems pharmacology study investigating how Xinnaoxin tablets ameliorate high-altitude polycythemia-associated cardiac injury in a mouse model. It includes results from UPLC-Q-TOF-MS metabolite identification, blood parameter analysis, histopathology, echocardiography, and Western blot analyses of signaling pathways.

Use Cases

• Validate systems pharmacology models based on the described multi-level analysis of signaling pathways.
• Benchmark drug efficacy for high-altitude polycythemia based on reported blood parameters and erythropoietin levels.
• Study cardioprotective mechanisms under hypobaric hypoxia based on described oxidative stress and apoptosis protein data.
• Correlate bone marrow erythropoietic efficiency with cardiac injury markers based on the described CD71+ cell population analysis.

Strengths

• Data is associated with a detailed methodological description including UPLC-Q-TOF-MS and Western blot analyses.
• The study employs a multi-level assessment strategy covering blood parameters, hemorheology, histopathology, and molecular signaling.

Limitations

• The dataset is a 63.9 KB PDF, indicating a very limited scope, likely containing summary results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the research article text.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Zhihui Wang.

Collection Method

Data generated from a hypobaric hypoxia mouse model study using UPLC-Q-TOF-MS, blood analysis, echocardiography, and Western blot.

Freshness

Last updated 2026-05-28 04:53:02; freshness should be verified.