CLL Cell-Derived Soluble Factors and Normal B Cell Functionality

A 4.4 MB PDF document details in vitro experiments testing the hypothesis that soluble factors from Chronic Lymphocytic Leukemia (CLL) cells impair normal B cell function. The data, authored by Michelle Maria Elbert and last updated in May 2026, includes measurements of plasma cell differentiation, proliferation, cell death, and activation markers CD80, CD86, and CD25. Results from the study suggest no major direct inhibitory effects of CLL-derived factors on normal B cells.

Use Cases

• Validate hypotheses about B cell immunosuppression in CLL based on in vitro functional assays.
• Compare B cell activation levels using CD80, CD86, and CD25 marker data from the description.
• Analyze plasma cell differentiation and proliferation outcomes from T-cell-dependent stimulation assays.
• Investigate the role of CLL patient serum versus conditioned medium from CLL cells on healthy donor B cells.

Strengths

• The dataset is associated with a detailed scientific methodology described in the PDF, including specific assays and control conditions.
• It is published under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• The dataset is stored as a 4.4 MB PDF; the underlying structured data, column definitions, and row counts are not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the PDF text after download.

Provenance

Source

figshare

Collection Method

Functional B-cell assays using serum from CLL patients and conditioned medium from CLL cells cultivated with stromal cells.

Freshness

Last updated 2026-05-15 05:52:07