Laron Mouse Liver RNA-Seq Data from GH Receptor Gene Therapy Study

RNA sequencing data from a mouse model of Laron syndrome (GH-resistant Ghr-/- mice) treated with liver-specific GH receptor gene therapy. The dataset, authored by Joshua K. Tay and shared under CC-BY-4.0, compares liver gene expression across wild-type, untreated Laron, treated Laron, and vector control groups. It includes results for 448 significantly changed genes in the treatment group and 2781 genes altered in the GHR-/- condition.

Use Cases

• Identify sex-biased gene expression patterns based on the enrichment for sex-biased genes noted in the description.
• Analyze the upregulation of specific proto-oncogenes like Ascl1 and Tmprss4 following gene therapy treatment.
• Compare the efficacy of gene therapy by examining the fold-change of IGF signaling genes (Igf1, Igfals) relative to controls.
• Study the broader transcriptomic impact of GH receptor loss by analyzing the 2781 differentially expressed genes in GHR-/- mice.

Strengths

• Includes data from four distinct experimental groups (wild-type, Laron, treated, vector control) for comparative analysis.
• Reports specific, quantified gene expression changes, including a 16-fold upregulation of Igf1 and Igfals in the treatment group.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small (86.4 KB), suggesting it contains summary results rather than raw sequencing reads.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

figshare, author Joshua K. Tay.

Collection Method

RNA sequencing (RNA-seq) performed on mouse livers from controlled laboratory experiments.

Freshness

Last updated 2026-05-28 04:56:29; freshness should be verified.