Plasma Exosomal Proteomics for Thyroid Disorders, Including Papillary Carcinoma

Proteomic data from plasma-derived exosomes identifies biomarkers for papillary thyroid carcinoma (PTC) in patients with Hashimoto’s thyroiditis. The dataset includes results from an integrative discovery study analyzing samples from patients with PTC, PTC with Hashimoto’s, Hashimoto’s alone, and healthy controls. It was authored by Yawei Zhang and last updated on 2026-05-25.

Use Cases

• Validate candidate biomarkers like SVEP1 and IGKV3-7 based on the parallel reaction monitoring (PRM) validation mentioned.
• Analyze pathways implicated in thyroid cancer progression based on the extracellular matrix (ECM)–receptor interactions and immune response pathways described.
• Compare exosomal protein profiles between papillary thyroid carcinoma with and without Hashimoto’s thyroiditis based on the patient cohorts described.

Strengths

• Identifies 45 differentially expressed proteins (DEPs) between key patient groups.
• Includes validation via parallel reaction monitoring (PRM), confirming two specific biomarkers.
• Released under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (168.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Exosome isolation and label-free quantitative proteomics applied to plasma samples from 12 patients across four groups.

Freshness

Last updated 2026-05-25 04:44:41; freshness should be verified.