Mouse Lung Proteomics and Cytokine Data for Millettia Speciosa Asthma Treatment Study

A proteomic dataset from a 2026 study investigating the therapeutic effects of the herb Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. The data includes results from high-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling, identifying 179 differentially expressed proteins. It was authored by Hangrui Yang and shared under a CC-BY-4.0 license.

Use Cases

• Identify key protein biomarkers for eosinophilic asthma based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in allergic inflammation based on the described suppression of CCL24.
• Analyze immunometabolic pathway modulation in asthma treatment based on described changes in complement/coagulation, lipid transport, and PPAR signaling.
• Study the potential gut-lung axis mechanisms in asthma based on the described molecular signatures aligning with microbiota-mediated modulation.

Strengths

• Includes proteomic data from a controlled mouse model experiment, providing a mechanistic view of treatment effects.
• Identifies a specific, key finding of complete CCL24 suppression in treated mice.
• Functional enrichment and network analyses are described, providing context for the 179 differentially expressed proteins.

Limitations

• The dataset is very small at 108.5 KB, suggesting limited raw data or a summary document.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data format is a PDF, which may require extraction to access structured data.

Provenance

Source

Hangrui Yang via figshare.

Collection Method

Generated from a laboratory study using an ovalbumin-induced mouse model of allergic asthma and analyzed with DIA proteomics and cytokine profiling.

Freshness

Last updated 2026-06-03 07:42:26.