Mouse Brain Transcriptomic Profiles for High-Altitude Cerebral Injury and Oxygen Therapy

A 46.1 KB PDF data sheet from a 2026 study by Xiaojie Hu details transcriptomic profiling of mouse brain tissue. The study used RNA sequencing to analyze four groups: control, high-altitude exposure, and two oxygen therapy treatments. Results include pathway enrichment analyses and validation data for oxidative stress and neuroinflammatory markers.

Use Cases

• Analyze gene expression changes in high-altitude cerebral injury based on RNA-seq data.
• Compare the effects of normobaric versus hyperbaric oxygen therapy on neuroinflammatory pathways.
• Validate transcriptomic findings with protein-level data for pathways like PI3K-AKT and TLR4-NF-κB.
• Investigate correlations between oxidative stress markers (SOD, MDA, GSH, NO) and transcriptomic profiles.

Strengths

• Data is associated with a detailed experimental protocol using a simulated altitude of 7,000m and defined oxygen therapy regimens.
• Includes multi-modal validation data from Western blot, immunofluorescence, and ELISA alongside RNA-seq.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (46.1 KB), suggesting it is a summary data sheet rather than the full underlying data.

Provenance

Source

figshare, author Xiaojie Hu.

Collection Method

Data generated from a controlled laboratory study using a mouse model in a hypobaric hypoxia chamber.

Time Range

Study details from 2026, but specific data collection dates are unknown.

Freshness

Last updated 2026-04 13 05:49:16; freshness should be verified.

Geography

Laboratory study; geographic origin of subjects or institution is unknown.