Xinnaoxin Tablets: Mouse Model Data on High-Altitude Cardiac Injury

A research article from figshare, authored by Zhihui Wang and last updated on 2026-05-28, details a study on Xinnaoxin tablets for high-altitude polycythemia and cardiac injury. The 98.1 KB PDF describes a mouse model experiment using systems pharmacology and multi-level analysis to investigate therapeutic mechanisms. Data includes blood parameters, hemorheology, cytokine levels, echocardiography, and Western blot analyses of signaling pathways.

Use Cases

• Study the effects of hypobaric hypoxia on blood parameters and cardiac function based on described hematological and echocardiography assessments.
• Analyze the modulation of NF-κB, MAPK, and PI3K/AKT signaling pathways based on the Western blot data mentioned in the description.
• Investigate the relationship between bone marrow erythropoiesis and systemic inflammation based on CD71+ cell proportions and cytokine levels.
• Model drug mechanisms using systems pharmacology approaches based on the described integrated strategy of metabolite identification and pathway analysis.

Strengths

• The description provides a detailed methodological account, including UPLC-Q-TOF-MS analysis and assessments across hematology, histopathology, and molecular signaling.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.
• The study employs a multi-level analysis strategy, combining systems pharmacology with in vivo mouse model data.

Limitations

• The dataset is a 98.1 KB PDF, suggesting it is a research article or data sheet rather than a raw, structured data repository.
• Column-level documentation and sample data are unavailable, requiring manual extraction of information from the text.
• The row count and data structure are unknown, limiting suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Data generated from a laboratory mouse model simulating high-altitude hypoxic conditions, with analyses including UPLC-Q-TOF-MS, blood tests, echocardiography, and Western blot.

Freshness

Last updated 2026-05-28 04:53:01; freshness should be verified.