CLL Cell-Derived Soluble Factors and Normal B Cell Functionality

A research dataset from a study investigating the influence of soluble factors from chronic lymphocytic leukemia (CLL) cells on normal B cell functionality. The dataset likely contains results from functional B-cell assays measuring plasma cell differentiation, proliferation, cell death, and activation markers CD80, CD86, and CD25. The data was published by Michelle Maria Elbert on figshare under a CC-BY-4.0 license and last updated on 2026-05-15.

Use Cases

• Analyze B cell activation levels based on CD80, CD86, and CD25 marker measurements mentioned in the description
• Compare plasma cell differentiation rates between B cells exposed to CLL patient serum and healthy control serum
• Assess B cell proliferation and cell death outcomes from in vitro co-culture experiments
• Investigate the hypothesis that soluble factors from CLL cells impair normal B cell function

Strengths

• Data is from a controlled experimental study with defined control groups (healthy donor serum, conditioned medium from normal B cells)
• Assays measured multiple functional outcomes: plasma cell differentiation, proliferation, cell death, and activation markers
• Published under a permissive CC-BY-4.0 license allowing reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (471.9 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Functional B-cell assays performed in vitro, as described in the associated research paper.

Freshness

Last updated 2026-05-15 05:52:11; freshness should be verified