Cryptosporidium Parvum Rhomboid Protease Phylogeny and Localization

Ilaria Vanni's 2026 study analyzes the rhomboid proteases in the Cryptosporidium parvum parasite. The dataset details phylogenetic origins, structural motifs, and subcellular localization for three rhomboids (CpRom1, CpRom2, CpRom3) in sporozoite cells. It includes comparisons across Cryptosporidium species and lists candidate substrate proteins.

Use Cases

• Classify rhomboid protease types (e.g., mixed secretases) based on structural domain analysis.
• Map subcellular localization patterns of CpRom1, CpRom2, and CpRom3 within sporozoites.
• Conduct phylogenetic clustering using catalytic site similarities with Toxoplasma gondii and Plasmodium falciparum orthologs.
• Identify candidate substrate membrane proteins based on similarity to known apicomplexan rhomboid substrates.
• Analyze genomic synteny and PARL-like gene excision events across Cryptosporidium species.

Strengths

• Analysis covers three specific rhomboid proteases (CpRom1, CpRom2, CpRom3).
• Includes cross-species comparison with gastric Cryptosporidium species (C. muris, C. andersoni).
• Provides subcellular localization details for each rhomboid in sporozoite stage.

Limitations

• Dataset is a single 122.7 KB PDF document, not a structured data table.
• No quantitative row or column counts are provided for computational analysis.
• Findings are specific to Cryptosporidium parvum, limiting generalizability to other parasites.

Provenance

Source

figshare, authored by Ilaria Vanni.

Collection Method

Phylogenetic, structural, and cellular localization analysis from a biological study.

Time Range

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Freshness

Last updated in April 2026.

Geography

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