Gene Therapy in Laron Mice: Liver RNA-seq Data on Growth Hormone Receptor

RNA-seq data from 448 genes shows significant expression changes in livers of GH-resistant mice after gene therapy. The dataset compares male and female mice across wild-type, Laron (GHR-/-), treated, and control groups. Joshua K. Tay published this data on figshare in May 2026.

Use Cases

• Analyze sex-biased gene expression patterns based on the enrichment for sex-biased genes mentioned in the description
• Investigate the effects of constitutive liver-specific promoters based on the unexpected upregulation of proto-oncogenes like Ascl1 and Tmprss4
• Compare gene therapy efficacy to IGF-1 treatment based on the limited increase in body length and weight described
• Study the restoration of GH-responsive pathways based on the 16-fold upregulation of Igf1 and Igfals genes

Strengths

• Includes data from four distinct experimental groups: wild-type, Laron, treated, and control
• Reports specific differential expression counts: 448 genes changed with treatment versus 2781 with GHR loss
• Contains RNA-seq data from both male and female mice, allowing for sex-difference analysis

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect experimental bias inherent to the specific mouse model and viral vector used

Provenance

Source

Joshua K. Tay

Collection Method

RNA sequencing performed on mouse livers from controlled laboratory experiments.

Freshness

Last updated 2026-05-28 04:56:31; freshness should be verified