Ankylosing Spondylitis Transcriptomic and Mendelian Randomization Results

Research data identifies integrated stress response genes as biomarkers for ankylosing spondylitis. The study combines transcriptomic profiling of patient blood with Mendelian randomization analysis. Results highlight downregulation of RORA and FBXO31 and increased expression of MSRB3.

Use Cases

• Validate the causal association of RORA, FBXO31, and MSRB3 gene expression with AS risk using Mendelian randomization results.
• Analyze correlations between identified biomarker expression levels and immune cell infiltration, particularly Th1 cells and keratinocytes.
• Investigate predicted therapeutic agents like indirubin and pentoxifylline based on the drug prediction analysis.
• Explore functional enrichment results, such as involvement in olfactory transduction pathways, for biological interpretation.

Strengths

• Includes results from both database analyses and clinical validation via RT–qPCR on blood samples.
• Applies multiple analytical methods: transcriptomic profiling, Mendelian randomization, functional enrichment, and drug prediction.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is very small at 11.2 KB, indicating limited scope and likely a summary of key findings rather than raw data.
• Unknown row and column structure prevents assessment of sample size or feature completeness.
• Relies on inferred causal associations from Mendelian randomization, which has specific methodological assumptions.

Provenance

Source

Shuai Wang via figshare.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, Mendelian randomization analysis, followed by functional enrichment, immune infiltration, drug prediction, and clinical validation.

Time Range

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Freshness

Last updated March 2026.

Geography

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