Mouse Lung Proteomic Data on Millettia Speciosa Treatment for Allergic Asthma

A proteomic dataset from a 2026 study investigating the therapeutic effects of Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. The dataset, authored by Hangrui Yang and shared under a CC-BY-4.0 license, includes results from high-resolution data-independent acquisition (DIA) lung proteomics and cytokine profiling. It identifies 179 differentially expressed proteins and highlights the suppression of the chemokine CCL24.

Use Cases

• Identify potential drug targets for asthma based on the 179 differentially expressed proteins.
• Study immunometabolic pathway modulation in lung tissue based on described changes in complement, coagulation, lipid transport, and PPAR signaling.
• Investigate the role of specific hub proteins (e.g., Alb, Apoe, Apoa1) in asthma pathology and treatment response.
• Validate findings related to the suppression of Th2 cytokines (IL-4, IL-5, IL-6) and IgE from the integrated bronchoalveolar lavage fluid analysis.

Strengths

• Identifies 179 differentially expressed proteins with statistical significance.
• Integrates proteomic findings with cytokine profiling (IgE, IL-4, IL-5, IL-6) for validation.
• Provides a detailed mechanistic hypothesis centered on CCL24 suppression and immunometabolic reprogramming.

Limitations

• The dataset is very small at 26.5 KB, suggesting limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• The proposed link to the gut-lung axis is noted as hypothetical and not directly investigated in the study.

Provenance

Source

Hangrui Yang, shared via figshare.

Collection Method

Generated from a controlled laboratory study using an ovalbumin-induced mouse model and DIA proteomics.

Freshness

Last updated 2026-06-03.