Whole-Exome Sequencing Data for Semen Quality Analysis in Three Russian Ethnic Groups

157 whole-exome sequenced samples from a Russian multiethnic population study of male fertility. The dataset includes samples from three ethnic groups—Slavs (59), Buryats (49), and Yakuts (49)—categorized by semen quality as pathozoospermia (95) or normospermia (62). Author Semyon Kolmykov published the data on figshare under a CC-BY-4.0 license, with a last update in April 2026.

Use Cases

• Identify genetic variants associated with impaired semen quality based on whole-exome sequencing data.
• Compare allele frequencies of candidate SNPs across Slavic, Buryat, and Yakut ethnic groups.
• Prioritize variants for further study based on testis expression and predicted functional effects.
• Validate potential SNP markers like rs6971091 or rs557806 in independent population samples.

Strengths

• Includes 157 whole-exome sequenced samples with defined ethnic and clinical groupings.
• Focuses on three distinct Russian ethnic groups (Slavs, Buryats, Yakuts) for population-specific analysis.
• Semen quality is classified using WHO-recommended reference limits for sperm concentration, motility, and morphology.
• Identifies nine specific SNP markers in seven testis-expressed genes for downstream verification.

Limitations

• Dataset is very small at 9.1 KB; row count and column-level documentation are unknown.
• The sample size of 157 individuals may limit statistical power for genetic association studies.
• Freshness should be verified; the last update date is in the future (2026-04-09).

Provenance

Source

figshare, author Semyon Kolmykov.

Collection Method

Whole-exome sequencing performed on 157 samples, with variant calling and filtering following GATK Best Practices. Association analysis used the χ2 test.

Freshness

Last updated 2026-04-09 03:03:44.

Geography

Russian Federation, with samples from Slavic, Buryat, and Yakut ethnic groups.