Mouse Phenotypic and Histological Data for PEG-ASNase-Induced Liver Injury

1.1 GB of data from a mouse study investigating drug-induced liver injury, supporting research described in PMID: 40177540. C57BL/6J mice were administered PEG-ASNase or a PBS control, with measurements including body weight, liver weight, and plasma biomarkers. The dataset, last updated in April 2026 and authored by Christian Fernandez, includes histological liver sections stained for steatosis, lipid peroxidation, and apoptosis.

Use Cases

• Modeling liver injury severity based on plasma biomarker levels like ALT and AST
• Correlating histological findings from H&E and TUNEL stains with phenotypic measurements
• Investigating the role of adipocyte lipolysis and lipotoxicity using non-esterified fatty acid (NEFA) data
• Assessing steatosis and lipid peroxidation through analysis of Oil Red O and 4-HNE stained images

Strengths

• Includes multiple data modalities: phenotypic measurements and histological image data
• Focuses on a specific, controlled experimental model using C57BL/6J mice with PEG-ASNase (1,500 IU/kg) or PBS control
• Measures a panel of relevant plasma biomarkers: ALT, AST, and NEFA
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is from a single mouse strain and a specific drug dose, limiting generalizability

Provenance

Source

Christian Fernandez

Collection Method

Generated from controlled mouse studies with intraperitoneal drug administration.

Time Range

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Freshness

Last updated 2026-04-20 19:21:13

Geography

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