LG268 RXR Agonist Effects on Breast Cancer Immune Microenvironment in Mouse Models

Four Excel datasets support a published study on the immunomodulatory effects of the RXR agonist LG268 in two mouse models of breast cancer. The data includes tumor and spleen weights, immune cell population counts from flow cytometry, and protein expression levels from Western blotting and PCR. The datasets are hosted on figshare and were generated by researchers at Michigan State University.

Use Cases

• Analyze changes in PD-L1 expression in cancer cells and macrophages based on treatment data.
• Compare tumor and spleen immune cell populations between MMTV-Neu and PyMT mouse models.
• Investigate CD4 and CD8 T cell activation levels following LG268 treatment.
• Correlate tumor weight with specific immune cell populations in the tumor microenvironment.

Strengths

• Datasets are directly linked to a peer-reviewed published article, providing context and validation.
• Data covers two distinct mouse models (HER2+ and TNBC) for comparative analysis.
• Multiple experimental methods are represented, including flow cytometry, Western blot, and PCR.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to preclinical mouse models, which may not directly translate to human biology.

Provenance

Source

figshare repository (DOI: 10.6084/m9.figshare.9944942) and supplementary files of the related article.

Collection Method

Generated from laboratory experiments including Western blotting, flow cytometry, and quantitative PCR on mouse models and cell lines.