MTHFR Genetic Variants and Depression Clinical Profiles

78 adult outpatients with DSM-5–diagnosed Major Depressive Disorder were analyzed for MTHFR gene variants and predicted enzymatic activity. Juliana Brum Moraes published this clinical study dataset on figshare in April 2026. It includes data on depressive severity, functional impairment, suicidality, adverse childhood experiences, and treatment resistance.

Use Cases

• Analyze associations between MTHFR 677C>T and 1298A>C genotypes and predicted enzymatic activity groups.
• Model depressive symptom severity (HDRS-17 scores) as a function of MTHFR activity group and adverse childhood experience (ACE) scores.
• Investigate correlations between reduced MTHFR activity and clinical variables like frequency of recurrent episodes or suicide attempts.
• Examine the relationship between MTHFR enzymatic activity and treatment complexity metrics, such as antipsychotic augmentation use.

Strengths

• 78 patient records with detailed clinical and genetic profiling
• Includes standardized assessment scores for depression (HDRS-17), functional impairment, and adverse childhood experiences

Limitations

• Small sample size of 78 participants limits statistical power and generalizability
• Cross-sectional observational design prevents causal inference
• Dataset size is 247.0 KB, indicating a limited scope with likely few variables beyond those described

Provenance

Source

figshare, author Juliana Brum Moraes

Collection Method

Cross-sectional observational study of adult outpatients with MDD who had available pharmacogenetic testing.

Time Range

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Freshness

Last updated April 2026.

Geography

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