PTIP and EphA2 Expression Data in Esophageal Squamous Cell Carcinoma

A research document analyzing the role of Pax2 transactivation domain-interacting protein (PTIP/PAXIP1) in esophageal squamous cell carcinoma (ESCC). The study uses immunohistochemistry, RNA-seq, and ChIP-seq data to investigate PTIP's regulation of EphA2 expression and its impact on cancer cell invasion. The document was authored by Xiao Han and last updated on 2026-05-28.

Use Cases

• Investigate the association between PTIP expression and lymph node metastasis in ESCC based on immunohistochemistry data.
• Study the regulatory relationship between PTIP and EphA2 expression based on integrated RNA-seq and ChIP-seq analysis.
• Model the impact of PTIP depletion on ESCC cell migration and invasion based on in vitro and in vivo loss-of-function experiments.
• Explore PTIP as a potential therapeutic target for inhibiting ESCC invasion based on its competition with Fosl2.

Strengths

• Data integrates multiple experimental methods, including immunohistochemistry, RNA-seq, and ChIP-seq.
• The document provides a specific molecular mechanism linking PTIP to EphA2 expression and cell invasion.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 14.1 KB DOCX file, indicating a very limited scope likely focused on textual results and figures.
• Column-level data and sample data are unavailable, requiring manual inspection after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Research study involving immunohistochemistry of ESCC tissues and in vitro/in vivo experiments.

Freshness

Last updated 2026-05-28 11:53:42; freshness should be verified.