Genetic Causal Links Between Common Mental Disorders and Asthma

A 875.9 KB PDF presents results from genetic analyses examining bidirectional causal links between common mental disorders and asthma. The study by Zian Yan, last updated in April 2026, used linkage disequilibrium score regression and bidirectional two-sample Mendelian randomization on summary statistics from large-scale Genome-Wide Association Studies in European populations. It found major depressive disorder is a predisposing factor for asthma, while anxiety disorders and asthma do not show a significant causal relationship.

Use Cases

• Investigate genetic correlations between mental disorders and asthma based on LDSC results
• Perform causal inference analysis using Mendelian randomization methods described in the study
• Validate findings on the independent effect of MDD on asthma risk after adjusting for BMI and alcohol consumption
• Explore the genetic architecture shared by anxiety, depression, and asthma traits

Strengths

• Analysis is based on summary statistics from recent large-scale Genome-Wide Association Studies
• Employs multiple genetic analysis methods: LDSC and bidirectional two-sample MR
• Includes multivariate MR adjusting for body mass index and alcohol consumption
• Published under a CC-BY-4.0 license for open reuse

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect geographic bias inherent to the source, as it is based on European population GWAS

Provenance

Source

figshare

Collection Method

Genetic analyses (LDSC, MR) performed on summary statistics from GWAS

Freshness

Last updated 2026-04-27 11:19:41; freshness should be verified

Geography

European populations