Molecular Defects in Cardiac Myofilament Ca2+ Regulation Due to Cardiomyopathy Mutations

Alice Sheehan's dataset likely contains results from an in vitro motility assay screening 40 compounds related to C-terminal Hsp90 inhibitors. The data supports findings that 23 compounds could restore the coupled relationship between Ca2+-sensitivity and troponin I phosphorylation in mutant thin filaments. The dataset was last updated on March 19, 2026.

Use Cases

• Screen small molecules for 're-coupling' activity based on in vitro motility assay results
• Analyze the relationship between Ca2+-sensitivity and troponin I phosphorylation based on mutant thin filament data
• Compare compound efficacy across 15 tested cardiomyopathy-linked mutations
• Identify structural features of compounds that confer independent re-coupling or desensitizing properties

Strengths

• Dataset includes results from screening 40 compounds
• Analysis covers 15 cardiomyopathy-linked mutations
• Quantitative results include Ca2+-sensitivity shift measurements (e.g., 2.2 ± 0.01-fold)
• Data is licensed under CC-BY-4.0 for open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is stored in a PDF format (1.9 MB), which may require extraction for analysis

Provenance

Source

Alice Sheehan via figshare

Collection Method

Likely generated from quantitative in vitro motility assays.

Freshness

Last updated 2026-03-19 11:28:13