JY5 Formula: Anti-Fibrotic Effects via Notch Signaling in Rodent Models

A novel Chinese medicine formula, JY5, significantly alleviated hepatic hydroxyproline content and collagen deposition in carbon tetrachloride- and bile duct ligation-induced fibrotic livers in rats and mice. The dataset, shared by Yadong Fu on figshare under CC-BY-4.0, contains results from in vivo and in vitro studies investigating this anti-fibrotic compound. It provides a scientific basis for the JY5 formula's potential as a therapeutic candidate for liver fibrosis.

Use Cases

• Validate anti-fibrotic drug efficacy based on hydroxyproline and collagen deposition measurements
• Study hepatic stellate cell activation pathways based on Notch signaling inhibition data
• Compare therapeutic effects across different liver fibrosis models (CCl4 and BDL)
• Identify active ingredients for drug formulation based on the composition of salvianolic acid B, schisantherin A, and amygdalin

Strengths

• Data is derived from multiple experimental models (CCl4 and BDL) in two species (rats and mice), suggesting cross-model validation.
• The study identifies a specific three-ingredient formula (JY5) and a proposed molecular mechanism (Notch pathway inhibition).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

figshare

Collection Method

Data likely contains results from quantitative analysis of FZHY extracts, in vivo uniform design studies, and in vitro cell activation models.

Freshness

Last updated 2026-05-18 11:59:42; freshness should be verified.