JY5 Formula: Anti-Fibrotic Compound Data from Rat and Mouse Liver Studies

Experimental data from a study investigating the JY5 formula, a novel Chinese medicine composed of salvianolic acid B, schisantherin A, and amygdalin. The dataset likely contains results from in vivo experiments using carbon tetrachloride- and bile duct ligation-induced liver fibrosis models in rats and mice, and in vitro tests on LX-2 cells. The research was authored by Yadong Fu and last updated on the figshare platform in May 2026.

Use Cases

• Validate the anti-fibrotic effects of the JY5 formula based on hepatic hydroxyproline content measurements.
• Investigate the mechanism of hepatic stellate cell activation inhibition based on Notch signaling pathway data.
• Compare the efficacy of the JY5 formula across different liver fibrosis models (CCl4 and BDL) mentioned in the study.

Strengths

• Dataset is associated with a specific, peer-reviewed research study with a clear mechanistic hypothesis (inhibition of the Notch pathway).
• Experiments were conducted using multiple, established animal models of liver fibrosis (CCl4 and BDL).
• The dataset is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• The 21.9 MB file size suggests a relatively small dataset, potentially limiting the scope of analysis.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on animal models and cell cultures as part of a pharmacological study.

Freshness

Last updated 2026-05-18 11:59:43; freshness should be verified.