JY5 Formula: Anti-Fibrotic Compound Data from Rat and Mouse Models

A novel Chinese medicine formula JY5, composed of salvianolic acid B, schisantherin A, and amygdalin, alleviated hepatic fibrosis in animal models. Data likely contains results from carbon tetrachloride- and bile duct ligation-induced liver fibrosis models in rats and mice, and an LX-2 cell activation model. The dataset was uploaded by Yadong Fu on figshare in May 2026.

Use Cases

• Validate anti-fibrotic effects of compound combinations based on hydroxyproline content and collagen deposition measurements
• Analyze hepatic stellate cell activation inhibition based on in vitro and in vivo model results
• Study the Notch signaling pathway inactivation mechanism described in the research
• Compare therapeutic efficacy across different liver fibrosis induction models (CCl4 and BDL)

Strengths

• Dataset is associated with a specific, peer-reviewed research study investigating a novel compound.
• The underlying research used multiple validation models (CCl4, BDL, TGF-beta1-induced LX-2 cells).
• The main active ingredients of the formula are explicitly identified: salvianolic acid B, schisantherin A, and amygdalin.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 18.4 MB size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on rat and mouse models and cell cultures.

Freshness

Last updated 2026-05-18 11:59:44; freshness should be verified.