DBU-Promoted Cascade Cyclization/Thiolation Experimental Data

24.5 MB of experimental data on a DBU-promoted cyclization/thiolation cascade for synthesizing 5-sulfenylated γ-lactams. The dataset, authored by Julia Poletto and last updated in May 2026, reports yields up to 98% with a broad N-aryl/N-alkyl scope and diverse sulfur nucleophiles. It includes control and in situ NMR experiments supporting a nucleophile-initiated mechanism.

Use Cases

• Training predictive models for reaction yield based on reported substrate scope and nucleophile diversity.
• Analyzing reaction mechanisms based on the described control and in situ NMR experiments.
• Identifying promising γ-lactam scaffolds for drug discovery based on the functional richness mentioned.
• Benchmarking new synthetic methods against the reported high-yield cascade reaction.

Strengths

• Reports high experimental yields of up to 98%.
• Covers a broad substrate scope including diverse N-aryl/N-alkyl groups and sulfur nucleophiles.
• Includes mechanistic data from control and in situ NMR experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Julia Poletto via figshare

Collection Method

Experimental chemical synthesis and analysis.

Time Range

Publication date suggests data is contemporary to 2026.

Freshness

Last updated 2026-05-04 18:43:12; freshness should be verified.

Geography

Laboratory-based; geographic origin is unknown.