Pirfenidone and Nintedanib Multi-Organ Fibrosis Targets and Pathways

72 protein targets for pirfenidone and 27 for nintedanib were identified from databases like CTD and STITCH. The dataset, authored by Vishal S. Patil and last updated in May 2026, maps these drug targets to fibrosis-related genes across nine organs. It includes pathway enrichment analysis results from KEGG, Reactome, and WikiPathways.

Use Cases

• Compare drug target overlap across organ-specific fibrosis based on the identified gene lists.
• Analyze conserved fibrotic signaling pathways (e.g., IL-17, TNF, TGF-β) modulated by the drugs.
• Identify potential new therapeutic applications for pirfenidone and nintedanib beyond lung fibrosis.
• Validate network pharmacology predictions using the provided drug-target interaction data.

Strengths

• Lists specific counts of drug targets per organ (e.g., 38 lung fibrosis targets for pirfenidone).
• Integrates data from multiple authoritative sources including GeneCards, KEGG, and BindingDB.
• Includes pathway enrichment results from three major databases (KEGG, Reactome, WikiPathways).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect source bias inherent to the integrated databases.

Provenance

Source

figshare

Collection Method

Targets retrieved from GeneCards and drug-target data collected from CTD, STITCH, KEGG, BindingDB, and TargetNet.

Freshness

Last updated 2026-05-30 17:48:46; freshness should be verified.