Murine Cardiomyocyte Gene Expression After Proton and Iron Particle Radiation Exposure

Transcriptome profiling data from isolated left ventricular murine cardiomyocytes exposed to 90 cGy proton and 15 cGy iron particle radiation. The dataset includes measurements taken at 1, 3, 7, 14, and 28 days post-exposure, with analysis identifying key regulatory gene networks. The data was produced by the National Aeronautics and Space Administration and was last updated in March 2026.

Use Cases

• Identify long-lasting gene expression signatures in cardiomyocytes based on the time-series measurements up to 28 days after exposure.
• Analyze differential transcript modulation between proton and iron particle radiation based on the described clustering results.
• Model signal transduction networks involving p38 MAPK and NFATc4 based on the protein validation mentioned in the description.
• Infer activity of transcription factors like GATA-4, STAT-3, and NF-kB at specific post-exposure time points based on the described assays.

Strengths

• Includes measurements at five specific time points (1, 3, 7, 14, and 28 days) after radiation exposure.
• Compares responses to two distinct radiation types (90 cGy proton and 15 cGy iron particles).
• Analysis includes network categorization into functional groups like cell cycle and oxidative responses.
• Protein validation was performed to support the identified signal transduction mechanisms.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Transcriptome profiling and network analysis of isolated murine cardiomyocytes after controlled radiation exposure.

Time Range

Measurements taken at 1, 3, 7, 14, and 28 days post-exposure.

Freshness

Last updated 2026-03 13 19:15:15.893930; freshness should be verified.

Geography

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