ASFV D345L Gene Deletion: Viral Replication and Immune Response Data

Xuefei Sun's dataset on figshare describes research into the African swine fever virus (ASFV) gene D345L. The data likely contains experimental results showing that deletion of this gene attenuates the virus and induces protective immunity in pigs. The dataset was last updated on 2026-05-25.

Use Cases

• Analyzing the impact of gene deletion on viral replication based on in vitro assay results described.
• Studying host immune responses, including cytokine up-regulation and interferon pathways, based on findings in porcine alveolar macrophages.
• Evaluating vaccine candidate efficacy based on protection rates against homologous and heterologous challenge strains.
• Investigating virulence-related genes for ASFV pathogenesis based on the identified correlation with viral replication and host antiviral response.

Strengths

• Dataset includes specific experimental outcomes, such as 80% protection against homologous challenge and 60% against heterologous challenge.
• Research is clearly attributed to an author (Xuefei Sun) and is openly licensed under CC-BY-4.0.
• The dataset description provides detailed biological mechanisms, including protein localization and effects on cytokine levels.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (3.1 MB), suggesting it may contain summary documents and images rather than large-scale raw data.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from virology and immunology research.

Freshness

Last updated 2026-05-25 13:52:02; freshness should be verified.