Trp53 Null Mammary Tumor RNA Expression After Heavy Ion Radiation

A 600-day study of tumor appearance in BALB/c mice transplanted with Trp53 null mammary fragments after exposure to sparsely ionizing gamma radiation or densely ionizing silicon particles at doses of 10, 30, or 80 cGy. The dataset contains total RNA extracted from 45 tumors, analyzed to compare expression profiles associated with tumor aggressiveness and metastasis. Data was produced by the National Aeronautics and Space Administration and last updated in March 2026.

Use Cases

• Modeling tumor growth kinetics based on radiation dose and type mentioned in the description
• Analyzing gene expression profiles associated with ER-negative, K18-positive tumor phenotypes
• Investigating the role of the irradiated microenvironment in promoting metastasis
• Comparing pathways like ERBB2, KRAS, Notch signaling, and mammary stem cell markers between tumor types

Strengths

• Data from a controlled 600-day longitudinal study monitoring tumor appearance and growth
• Includes 45 tumor samples across four distinct experimental groups (sham, 10 cGy, 30 cGy, 80 cGy)
• Expression profiles compare specific tumor subtypes (K18 vs K14/18) with links to aggressiveness and metastasis

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is stored in a BIN format, which may require specialized tools for access and analysis

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental study involving irradiation of BALB/c mice and transplantation of syngeneic Trp53 null mammary fragments, followed by RNA extraction from resulting tumors.

Time Range

Study monitored for 600 days; specific collection dates are not provided.

Freshness

Last updated 2026-03-13 19:12:41.894918; freshness should be verified

Geography

Laboratory study; geographic coverage is not specified.