Design and Evaluation of Ga-68-Labeled ROR1-Targeted PET Probes

A series of PR7-derived radiotracers, including linear and cyclic analogues, were developed and evaluated for imaging ROR1 expression. The dataset likely contains results from in vitro and in vivo specificity tests, including stability measurements over 90 minutes and tumor accumulation data within 30 minutes post-injection in MC38 tumor-bearing mice. Author Tao Yang published the data on figshare under a CC-BY-NC-4.0 license in May 2026.

Use Cases

• Compare tumor targeting efficiency based on the described tumor-to-nontumor ratios from PET imaging.
• Evaluate in vivo metabolic stability of peptide-based probes based on the comparison with a previous F-18 labeled tracer.
• Analyze the impact of peptide optimization strategies like N-methylation and carboxyl amidation on probe performance.
• Assess clearance pathways of radiotracers based on the noted predominant renal clearance.

Strengths

• Includes data from systematic in vitro and in vivo evaluation of multiple radiotracer analogues.
• Reports specific performance metrics, such as high stability in saline and fetal bovine serum for at least 90 minutes.
• Compares a leading candidate ([68Ga]Ga-LP4) against a previously reported probe, providing a benchmark.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 5.1 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from the development and evaluation of peptide-based PET probes.

Freshness

Last updated 2026-05-27 03:04:48; freshness should be verified.