Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcon

A series of new chalcones containing a fluorine atom at the B ring were designed, synthesized, and evaluated for antiproliferative activity against a panel of human tumor cell lines. The dataset, from a paper by Serdar Burmaoğlu, includes results for specific analogs, such as compounds 8, 9, 12, 45, 46, and 48, which showed activity against certain tumor cells without cytotoxicity towards normal HEK 293 cells. Activity was supported by acridine orange staining, xCELLigence assays, and in silico molecular docking studies against tubulin protein.

Use Cases

• Training predictive models for antiproliferative activity based on chalcone derivative structures.
• Analyzing structure-activity relationships for fluorine-containing compounds against specific tumor cell lines.
• Validating molecular docking simulations against tubulin protein using experimental activity data.
• Comparing the cytotoxic effects of synthesized analogs between tumor cells and normal HEK 293 cells.

Strengths

• Experimental data includes evaluation against a panel of human tumor cell lines.
• Results are supported by multiple assays: acridine orange staining, xCELLigence assay, and in silico molecular docking.
• Specific active compounds (8, 9, 12, 45, 46, 48) are identified with concentration-dependent activity data for some.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Experimental design, synthesis, and biological evaluation described in the associated research paper.