5F Michael Adducts: Synthesis and Antitumor Evaluation of Novel Diterpenoid Derivatives

Compound 29, a novel derivative of the diterpenoid 5F, demonstrated a 7-fold increase in potency against HCT116 cancer cells compared to its parent compound. The dataset describes the design, synthesis, and biological evaluation of a series of these derivatives, including in vivo results from HCT116 xenograft nude mice. Author Chen-Liang Zhao published this research under a CC-BY-4.0 license on figshare in April 2026.

Use Cases

• Analyzing structure-activity relationships based on the synthesis of a novel series of 5F derivatives.
• Comparing in vitro antiproliferative potency based on IC50 values against a panel of human cancer cell lines.
• Evaluating in vivo antitumor efficacy and reduced toxicity based on HCT116 xenograft nude mouse model results.

Strengths

• Includes specific quantitative results, such as a reported IC50 value of 0.957 μM for the lead compound.
• Provides comparative efficacy data against a standard chemotherapeutic agent (5-fluorouracil).
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data files are in PDF and DOC formats, which are less machine-readable than structured data formats.

Provenance

Source

figshare

Collection Method

Experimental research involving chemical synthesis and biological assays.

Freshness

Last updated 2026-04-25 06:40:04; freshness should be verified.