HSP90-Targeted Radiotracer Performance in Colorectal and Gastric Cancer Models

Ao Li developed a dataset on figshare describing the design and evaluation of a novel small molecule radiotracer targeting HSP90. The dataset includes quantitative measurements of tumor uptake and off-target retention in preclinical cancer models, with results from clinical evaluation. It was last updated on May 4, 2026.

Use Cases

• Benchmarking tumor uptake efficiency based on reported percentage injected dose per gram (ID/g) values.
• Evaluating off-target tracer accumulation based on liver and kidney retention data.
• Assessing imaging contrast potential based on reported tumor-to-muscle ratios and SUVmax values.

Strengths

• Includes specific quantitative results for tumor uptake (e.g., 10.02 ± 2.05% ID/g in colorectal models).
• Reports reduced off-target retention in liver (~2% ID/g) and kidney (~5% ID/g).
• Provides high tumor-to-muscle contrast ratios (e.g., 23.28 ± 9.70).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (1.2 KB), indicating a limited scope of data.

Provenance

Source

figshare, author Ao Li.

Collection Method

Likely contains synthesized experimental results from the development and optimization of a radiotracer.

Freshness

Last updated 2026-05-04 08:04:16; freshness should be verified.