Podophyllotoxin Derivative Structures for Esophageal Cancer Treatment

Manwei Jia published a dataset on figshare in April 2026 containing structural data for novel podophyllotoxin derivatives designed to target LAT1 transporters. The data likely includes molecular structures and properties for compounds synthesized to improve safety and efficacy against esophageal cancer. The dataset is 1.0 MB in size and is licensed under CC-BY-NC-4.0.

Use Cases

• Predicting compound activity based on structural features mentioned in the description
• Analyzing structure-activity relationships for LAT1-targeted conjugates
• Modeling pharmacokinetic properties like tumor distribution from molecular data

Strengths

• Includes data for a specific compound (B11) with reported 64.6% tumor growth inhibition
• Compounds were designed with a specific targeting mechanism (LAT1-dependent accumulation)
• Dataset is focused on a clear therapeutic area (esophageal cancer treatment)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect experimental bias inherent to the single-study source on figshare

Provenance

Source

Manwei Jia

Collection Method

Likely contains data from chemical synthesis and biological experiments described in the research.

Time Range

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Freshness

Last updated 2026-04-14 08:16:50; freshness should be verified

Geography

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