Os3 Complex: In-Vivo Anti-Tumor Efficacy Data for a Multi-Modal Cancer Therapy

Os3, a novel osmium(II) complex, demonstrated significant tumor growth inhibition and low side effects in an MC38 colon cancer xenograft model. The 1.8 KB dataset, authored by Minghui Zhu and last updated in April 2026, likely contains experimental results for this compound integrating photodynamic therapy, chemotherapy, and immunotherapy. Its antitumor effects are attributed to phototoxicity, DNA action, mitochondrial damage, and ferroptosis-mediated immune response.

Use Cases

• Benchmarking the in-vivo efficacy of novel osmium complexes based on tumor growth inhibition data.
• Analyzing the relationship between phototoxicity and cytotoxicity in cancer cells based on the described mechanism.
• Modeling the combined effects of photodynamic therapy, chemotherapy, and immunotherapy from a single agent.
• Investigating ferroptosis-mediated immune responses triggered by metal-based drugs.

Strengths

• Dataset is small at 1.8 KB, facilitating quick download and inspection.
• Specific compound (Os3) and its multi-modal therapeutic approach are clearly described.
• In-vivo efficacy was demonstrated in a defined MC38 colon cancer xenograft model.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Minghui Zhu via figshare

Collection Method

Likely contains experimental results from the design and testing of a novel osmium(II) complex.

Time Range

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Freshness

Last updated 2026-04-11 13:30:45; freshness should be verified.

Geography

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