Florfenicol Residue Depletion in Chicken Eggs from Dosed Laying Hens

A study of 50 laying hens divided into 5 dosing groups to determine the depletion of florfenicol (FF) and its metabolite florfenicol amine (FFA) in eggs. The analytes were extracted from yolk, albumen, and whole egg, purified, and analyzed by HPLC. Limits of detection were 1.94 ppb for FF and 0.48 ppb for FFA, with relative standard deviation values below 11%.

Use Cases

• Modeling antibiotic residue depletion over time based on different administration routes and durations described in the study
• Developing or validating HPLC-based detection methods for florfenicol and its metabolite in egg matrices
• Assessing food safety risks by analyzing the elimination percentages and times of drug residues from egg yolk

Strengths

• Provides specific detection and quantitation limits (1.94/6.45 ppb for FF, 0.48/1.58 ppb for FFA) and method precision (RSD < 11%)
• Describes a controlled experiment with 50 laying hens across 5 distinct dosing groups for comparative analysis

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Ayhan Filazı via paperswithcode

Collection Method

Experimental study where analytes were extracted from egg components, purified, and analyzed by HPLC.