68Ga-PDT01: Preclinical PET Imaging Data for PD-L1 Expression

A preclinical dataset describes the development and evaluation of a novel peptide-based PET tracer, 68Ga-PDT01, for imaging PD-L1 expression. The data, authored by Cong Wang and shared on figshare, includes results from in vitro binding assays and in vivo PET imaging in multiple subcutaneous tumor models. The dataset was last updated on June 1, 2026.

Use Cases

• Evaluating tracer binding affinity based on the reported KD value of 304 ± 26 nM
• Assessing tumor visualization potential based on tumor-to-muscle ratios >6.00 at 1 hour post-injection
• Modeling dynamic PD-L1 modulation based on the ~3.16-fold uptake increase following cisplatin treatment

Strengths

• Includes specific quantitative metrics, such as a binding affinity (KD) of 304 ± 26 nM
• Reports clear in vivo imaging results, including tumor-to-muscle ratios exceeding 6.00
• Demonstrates tracer sensitivity to dynamic changes with a ~3.16-fold uptake increase post-treatment

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small at 1019.0 B, indicating limited scope

Provenance

Source

figshare

Collection Method

Preclinical laboratory research involving cell binding assays and animal PET imaging.

Freshness

Last updated 2026-06-01 05:33:18; freshness should be verified