RP-HPLC Method for Simultaneous Estimation of Irbesartan and Atorvastatin

A reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Irbesartan and Atorvastatin in synthetic mixture. The method was developed by Virani Paras and uses an Inertsil C18 column with a mobile phase of Acetonitrile and 0.1% Formic acid. Retention times for Irbesartan and Atorvastatin were 3.993 and 7.733 minutes, with linearity ranges of 400-800 and 50-100 μg/ml and recovery percentages of 99.88% and 99.70%, respectively.

Use Cases

• Validate HPLC method performance based on reported retention times and linearity ranges.
• Compare recovery percentages for quality control of synthetic drug mixtures.
• Benchmark chromatographic conditions using the described mobile phase composition and pH.
• Assess method precision and accuracy for Irbesartan and Atorvastatin estimation.

Strengths

• Method reports specific linearity ranges (400-800 μg/ml for Irbesartan, 50-100 μg/ml for Atorvastatin).
• High correlation coefficient values (0.9995 and 0.9994) indicate strong linearity.
• Recovery percentages are quantified (99.88% and 99.70%).
• Chromatographic conditions are fully specified, including column, mobile phase, flow rate, and detection wavelength.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Virani Paras

Collection Method

Laboratory development and validation of an RP-HPLC analytical method.