Cannabinoid Quantification in Medicinal Cannabis Products via HPLC-UV

A methodology for quantifying cannabinoids in medicinal cannabis products available in Brazil. The method uses HPLC-UV with gradient elution and was tested on four cannabis-based products, meeting requirements for precision, accuracy, linearity, and selectivity. It was developed by Anna Sophia Conhasco Lanzellotti Dantas to address the lack of a monograph in the Brazilian Pharmacopoeia.

Use Cases

• Validate analytical methods for cannabinoid quantification based on the described HPLC-UV parameters.
• Assess the quality of medicinal cannabis products based on the reported precision and accuracy metrics for CBD and THC.
• Develop quality control protocols for cannabis-based products based on the established requirements of selectivity and linearity.

Strengths

• Method validated for precision, accuracy, linearity, and selectivity as stated in the description.
• Quantified CBD with recoveries of 105.35% and 104.07%, and THC at 106.62%.
• Procedure tested on four distinct cannabis-based products to attest effectiveness.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Anna Sophia Conhasco Lanzellotti Dantas via paperswithcode

Collection Method

Developed via HPLC-UV with a specific gradient elution composition, flow rate, and detection wavelength.

Geography

Brazil