UBHA HDAC Inhibitors: Structure-Activity Relationships and Bioassay Results

Francesco Fiorentino published a dataset on figshare in April 2026 describing biphenyl-substituted uracil-based hydroxamic acids (UBHAs). The data likely contains structure-activity relationships and bioassay results for synthesized compounds tested as HDAC inhibitors. The dataset is 8.1 KB in size.

Use Cases

• Analyze structure-activity relationships based on systematic cap group and linker modifications described
• Evaluate HDAC isoform selectivity profiles based on nanomolar inhibition data mentioned
• Model pro-apoptotic activity based on cell viability and gene modulation results in leukemia and prostate cancer cells

Strengths

• Includes data on compounds achieving nanomolar inhibition, particularly against HDAC6
• Describes lead candidates 14a and 14b with submicromolar dose efficacy
• Provides results from multiple cancer cell models (U937 and prostate cancer)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Francesco Fiorentino

Collection Method

Likely contains synthesized compound data and bioassay results from laboratory experiments.

Freshness

Last updated 2026-04-30 09:33:14