DNMT1 Fluorescent Probe Data for Cervical Cancer Cell Detection

Peijia Jin developed covalent fluorescent probes targeting DNA methyltransferase 1 (DNMT1) for tumor diagnosis. The dataset likely contains results from affinity assessments, in-gel fluorescence scans, and competitive assays in HeLa and cervical exfoliated cells. It was published on figshare in March 2026.

Use Cases

• Evaluating probe binding affinity based on surface plasmon resonance data mentioned in the description
• Assessing fluorescence performance in cell lines based on concentration- and time-dependent results
• Comparing diagnostic potential across cell types based on relative fluorescence unit ratios for cervical lesions

Strengths

• Includes data from competitive assays confirming covalent binding to DNMT1
• Contains results from clinical cervical exfoliated cells, indicating real-world diagnostic potential

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Experimental research constructing RG108 derivatives and performing affinity assessments, fluorescence scanning, and competitive assays.

Freshness

Last updated 2026-03-19 02:17:15; freshness should be verified